2-甲基-4-氧-4-苯基丁酸合成路线 （共 38 条）
参考文献
Morin,F.G.; Horton,W.J.; Grant,D.M.
Journal of the American Chemical Society, 1983 , vol. 105, p. 3992
参考文献
Krollpfeiffer; Schaefer
Chemische Berichte, 1923 , vol. 56, p. 630
反应条件
1: 75.9 percent / H2
2: 96.4 percent / acetyl chloride
3: benzene; diethyl ether / 3 h / Heating
View Scheme
参考文献
Morin,F.G.; Horton,W.J.; Grant,D.M.
Journal of the American Chemical Society, 1983 , vol. 105, p. 3992
参考文献
American Cyanamid Company
Patent: US4374249 A1, 1983 ;
US 4374249 A
反应条件
acetic anhydride
T=100°C;
参考文献
Hyde, Alan M.; Buchwald, Stephen L.
Organic Letters, 2009 , vol. 11, # 12 p. 2663 - 2666
反应条件
1: 94.3 percent / hydrazine monohydrate / aq. ethanol / 2 h / Heating
2: 91.1 percent / CuCl2 / acetonitrile / 2 h / Heating
3: 96 percent / POCl3 / acetonitrile / 2.5 h / Heating
View Scheme
参考文献
Hu, Wenhui; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M.; Behanna, Heather A.; Wing, Laura K.; Munoz, Lenka; Guo, Ling; Van Eldik, Linda J.; Watterson, D. Martin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 414 - 418
反应条件
1: 94.3 percent / hydrazine monohydrate / aq. ethanol / 2 h / Heating
2: 91.1 percent / CuCl2 / acetonitrile / 2 h / Heating
3: 96 percent / POCl3 / acetonitrile / 2.5 h / Heating
4: 74 percent / H2O / 72 h / 140 °C
View Scheme
参考文献
Hu, Wenhui; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M.; Behanna, Heather A.; Wing, Laura K.; Munoz, Lenka; Guo, Ling; Van Eldik, Linda J.; Watterson, D. Martin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 414 - 418
反应条件
hydrazine in ethanol
T=10 - 20°C; 2 h; Heating / reflux;
参考文献
NEUROMEDIX, INC.
Patent: WO2007/127448 A2, 2007 ;
Location in patent: Page/Page column 57 ;
