2-(叔丁基二甲基甲硅烷基氧基)-4-溴苯甲醚合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C;
参考文献
NOVARTIS AG
Patent: WO2009/118292 A1, 2009 ;
Location in patent: Page/Page column 52 ;
反应条件
1: 86 percent / MCPBA / CH2Cl2 / 48 h / Ambient temperature 2: 83 percent / imidazole / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Fuerstner, Alois; Nikolakis, Katharina
Liebigs Annales, 1996 , # 12 p. 2107 - 2113
反应条件
1H-imidazole; sulfuric acid; dihydrogen peroxide 1.) MeOH, 2.) DMF; Yield givenMultistep reaction;
参考文献
Miller, Thomas A.; Bulman, Amanda L.; Thompson, Charles D.; Macdonald, Timothy L.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 3 p. 407 - 412
反应条件
1: 1.) n-BuLi, 9-MeO-9-BBN / 2.) PdCl2(dppf) / 1.) THF, hexane, -78 deg C to r.t., 2.) reflux, 15 h 2: 74 percent / H2 / 5percent Pd/C, ethylenediamine / methanol / 0.42 h / 760 Torr 3: 95 percent / 70percent aq. TBAF / ethyl acetate / 0.5 h View Scheme
参考文献
Fuerstner, Alois; Nikolakis, Katharina
Liebigs Annales, 1996 , # 12 p. 2107 - 2113
