1: trimethyl-oxo-sulfonium iodide With sodium hydride; dimethyl sulfoxide in DMF (N,N-dimethyl-formamide)
T=0°C; 0.5 h;
2: (4-benzyl-morpholin-2-yl)-phenylmethanone in DMF (N,N-dimethyl-formamide)
0.5 h;
3: With water in DMF (N,N-dimethyl-formamide)
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/60949 A2, 2005 ;
Location in patent: Page/Page column 145 ;
WO 2005/060949 A2
Blade-Font, Artur; Rocabayera, Teodoro de Mas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 841 - 848