1,2,3,4-四氢喹啉-6-甲酸甲酯合成路线 （共 8 条）
反应条件
in tetrahydrofuran; diethyl ether T=-78 - 20°C; 6 h;
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 131 ;
反应条件
hydrogen; platinum(IV) oxide in trifluoroacetic acid T=20°C; P=760.051 Torr; 5 h;
参考文献
Journal of Organic Chemistry, , vol. 67, # 22 p. 7890 - 7893
参考文献
US6300342 B1, ;
US 6300342 B1
反应条件
in methanol; diethyl ether T=20°C; 2 h;
参考文献
US2006/178398 A1, ;
Page/Page column 21-22 ;
US 20060178398 A1
反应条件
in tetrahydrofuran; methanol; water; ethyl acetate
反应条件
thionyl chloride T=0 - 20°C;
参考文献
Zhang, Cunyu; Westaway, Susan M.; Speake, Jason D.; Bishop, Michael J.; Goetz, Aaron S.; Carballo, Luz Helena; Hu, Mike; Epperly, Andrea H.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 670 - 676
反应条件
1: 10 palladium on activated carbon; ammonium formate / methanol / 2 h / Reflux 2: thionyl chloride / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 2 p. 670 - 676
反应条件
1: With di-tert-butyl dicarbonate; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran
T=20°C; 72 h;
2: With lithium aluminium tetrahydride in tetrahydrofuran
T=20 - 65°C; 13 h;
3: With Potassium sodium tartrate in tetrahydrofuran; water; ethyl acetate
2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; HUBER, John D.; RAUDENBUSH, Brian Christopher; SARKO, Christopher Ronald
Patent: WO2012/122340 A1, 2012 ;
Location in patent: Page/Page column 54-55 ;
