反式-甲烷磺酸 4-叔丁氧基羰基氨基-环己酯合成路线 （共 4 条）
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 2.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water 0.5 h;
参考文献
Xiong, Hui; Frietze, William; Andisik, Donald W.; Ernst, Glen E.; Palmer, William E.; Hinkley, Lindsay; Varnes, Jeffrey G.; Albert, Jeffrey S.; Veale, Chris A.
Tetrahedron Letters, 2010 , vol. 51, # 51 p. 6741 - 6744
反应条件
1: sodium carbonate / dichloromethane; water / 20 °C 2: triethylamine / tetrahydrofuran / 0 - 17 °C / Inert atmosphere View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ZHANG, Beili; KRAWIEC, Mariusz; LUISI, Brian; MEDEK, Ales
Patent: WO2011/50220 A1, 2011 ;
WO 2011/050220 A1
反应条件
1.1: dichloromethane / 20 °C / Inert atmosphere 2.1: sodium hydroxide; water / dichloromethane / 25 °C 2.2: 0.5 h View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ZHANG, Beili; KRAWIEC, Mariusz; LUISI, Brian; MEDEK, Ales
Patent: WO2011/50220 A1, 2011 ;
WO 2011/050220 A1
反应条件
potassium tert-butylate in tetrahydrofuran
参考文献
Xiong, Hui; Frietze, William; Andisik, Donald W.; Ernst, Glen E.; Palmer, William E.; Hinkley, Lindsay; Varnes, Jeffrey G.; Albert, Jeffrey S.; Veale, Chris A.
Tetrahedron Letters, 2010 , vol. 51, # 51 p. 6741 - 6744
