1: 74 percent / 1.) n-butyllithium / hexane; tetrahydrofuran / 1.) -78 deg C, 20 min; 2.) -78 deg C, 10 min; to RT, 1.5 h 2: 83 percent / 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating View Scheme

1: 74 percent / 1.) n-butyllithium / hexane; tetrahydrofuran / 1.) -78 deg C, 20 min; 2.) -78 deg C, 10 min; to RT, 1.5 h 2: 83 percent / 1.) LiOH; 2.) HCl / acetone; H2O / 1.5 h / Heating 3: 82 percent / 1.) 1,1'-carbonyldiimidazole / CH2Cl2 / 1.) 0 deg C, 45 min; 2.) 0 deg C to RT, 14 h View Scheme