7-羟基-2,2-二甲基-苯并二氢吡喃-4-酮合成路线 （共 37 条）
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=80°C; 5 h;
参考文献
Timar, Tibor; Hosztafi, Sandor; Jaszberenyi, J. Csaba; Koever, Katalin E.; Batta, Gyula
Acta Chimica Hungarica, 1988 , vol. 125, # 2 p. 303 - 312
反应条件
1: 96 percent / K2CO3, KI / dimethylformamide / 5 h / 80 °C
2: NaBH4 / methanol / 0.5 h / 25 °C
3: 4 M HCl / tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Timar, Tibor; Hosztafi, Sandor; Jaszberenyi, J. Csaba; Koever, Katalin E.; Batta, Gyula
Acta Chimica Hungarica, 1988 , vol. 125, # 2 p. 303 - 312
反应条件
1: 85 percent / K2CO3, KI / dimethylformamide / 22 h / 80 °C
2: NaBH4 / methanol / 2 h / 25 °C
3: 4 M HCl / tetrahydrofuran / 3 h / 25 °C
View Scheme
参考文献
Timar, Tibor; Hosztafi, Sandor; Jaszberenyi, J. Csaba; Koever, Katalin E.; Batta, Gyula
Acta Chimica Hungarica, 1988 , vol. 125, # 2 p. 303 - 312
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
Heating;
参考文献
Lim, Jongdoo; Kim, Ik-Hwan; Kim, Hyeon Ho; Ahn, Kyung-Seop; Han, Hogyu
Tetrahedron Letters, 2001 , vol. 42, # 24 p. 4001 - 4003
反应条件
sodium hydroxide in tetrahydrofuran; magnesium
参考文献
Beecham Group Limited
Patent: US4080335 A1, 1978 ;
反应条件
pyridine; hydroxylamine hydrochloride in methanol
T=20°C;
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.
Patent: US2006/128689 A1, 2006 ;
Location in patent: Page/Page column 40 ;
反应条件
1: 94 percent / Et3N / CH2Cl2 / 0.58 h / -15 - 23 °C
2: 93 percent / formic acid; PPh3 / palladium(II) acetate / dimethylformamide / 0.83 h / 60 °C
View Scheme
参考文献
Sebok; Timar; Eszenyi; Patonay
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6318 - 6321
