氰基(苯基)甲基氨基甲酸叔丁酯合成路线 （共 11 条）
反应条件
hydrogenchloride; water 1 h; Reflux;
参考文献
Organic Letters, , vol. 12, # 2 p. 264 - 267
反应条件
triethylamine in tetrahydrofuran; dichloromethane; water
参考文献
Gabriel, Tobias; Pech, Michael; Wallbaum, Sabine
Patent: US2001/8901 A1, 2001 ;
反应条件
ethyl phosphorodichloridate; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane
T=20°C; 2 h;
参考文献
Sureshbabu, Vommina V.; Naik, Shankar A.; Nagendra
Synthetic Communications, 2009 , vol. 39, # 3 p. 395 - 406
反应条件
titanium tetra-n-butoxide; water; N-(2'-hydroxyphenyl)methyl-(S)-2-amino-3,3-dimethyl-butan-1-ol in toluene; butan-1-ol
T=20°C; 0.25 h; optical yield given as percent eeenantioselective reaction;
参考文献
Seayad, Abdul Majeed; Ramalingam, Balamurugan; Yoshinaga, Kazuhiko; Nagata, Takushi; Chai, Christina L. L.
Organic Letters, 2010 , vol. 12, # 2 p. 264 - 267
反应条件
1: C32H29N4OP With hydrogenchloride; methanol in water
T=20°C; 2 h;
2: di-tert-butyl dicarbonate With triethylamine in dichloromethane; water
T=20°C;
参考文献
Kaur, Parminder; Pindi, Suresh; Wever, Walter; Rajale, Trideep; Li, Guigen
Chemical Communications, 2010 , vol. 46, # 24 p. 4330 - 4332
反应条件
β-cyclodextrin in methanol; acetone
T=20°C; 2.5 h;
参考文献
Somi Reddy; Narender; Nageswar; Rama Rao
Synlett, 2006 , # 7 p. 1110 - 1112
反应条件
QNH in dichloromethane
T=-10°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Reingruber, Ruediger; Baumann, Thomas; Dahmen, Stefan; Braese, Stefan
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 7-8 p. 1019 - 1024
反应条件
cyclolt;(S)-Phe-(S)-α-amino-γ-guanidinobutyric acidgt; in methanol
T=-25°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Iyer; Gigstad; Namdev; Lipton
Journal of the American Chemical Society, 1996 , vol. 118, # 20 p. 4910 - 4911
反应条件
1.1: isopropyl alcohol / tetrahydrofuran; toluene / -78 - 20 °C / Inert atmosphere
1.2: 2 h / -78 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 2 h / 20 °C
3.1: triethylamine / dichloromethane / 6 h / 20 °C
View Scheme
参考文献
Kaur, Parminder; Wever, Walter; Pindi, Suresh; Milles, Raizada; Gu, Peng; Shi, Min; Li, Guigen
Green Chemistry, 2011 , vol. 13, # 5 p. 1288 - 1292
反应条件
1: hydrogenchloride; water / methanol / 2 h / 20 °C
2: triethylamine / dichloromethane / 6 h / 20 °C
View Scheme
参考文献
Kaur, Parminder; Wever, Walter; Pindi, Suresh; Milles, Raizada; Gu, Peng; Shi, Min; Li, Guigen
Green Chemistry, 2011 , vol. 13, # 5 p. 1288 - 1292
