1: With n-butyllithium in tetrahydrofuran; hexane; toluene T=-50°C; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane; toluene T=-50 - -15°C; 3: With sodium hydroxide in tetrahydrofuran; hexane; toluene

1: With n-butyllithium; diisopropylamine in tetrahydrofuran T=0 - 3°C; 2.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-38 - 20°C; 16 h; 3: With hydrogenchloride in tetrahydrofuran T=0 - 20°C; Further stages. Title compound not separated from byproducts.;

1: ethyl (3R)-1-[(Z)-4-iodo-4-(3-methyl-2-thienyl)-3-butenyl]hexahydro-3-pyridinecarboxylate With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=20°C; Suzuki coupling; 0.25 h; Inert atmosphere; 2: 6-(3-methylthiophen-2-yl)boronic acid in ethylene glycol dimethyl ether; ethanol; water T=90°C; Suzuki coupling; Inert atmosphere;