(R)-n-乙酰基-1-(4-溴苯基)乙胺合成路线 （共 14 条）
反应条件
hydrogen; (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a:3,4-a']dinaphthalen-4-yl)diethylamine; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in tetrahydrofuran
T=5°C; P=15514.4 Torr; 4 h;
参考文献
Jia, Xian; Li, Xingshu; Xu, Lijin; Shi, Qian; Yao, Xinsheng; Chan, Albert S. C.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4539 - 4541
反应条件
pyridine in dichloromethane
T=25°C; 3 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
US 20050176701 A1
反应条件
Candida antarctica lipase B; bis[(p-MeOC6H4)-4-cyclopentadienol]Ru2(CO)4; sodium carbonate in toluene
T=90°C; 72 h;
参考文献
Thalen, Lisa K.; Zhao, Dongbo; Sortais, Jean-Baptiste; Paetzold, Jens; Hoben, Christine; Baeckvall, Jan-E.
Chemistry - A European Journal, 2009 , vol. 15, # 14 p. 3403 - 3410
反应条件
lt;lt;(R,R)-1,2-bis(trans-2,5-dimethylphospholano)ethanegt;Rh(COD)gt;OTf; hydrogen in methanol
T=22°C; P=3102.9 Torr; 15 h; Title compound not separated from byproducts;
参考文献
Burk, Mark J.; Wang, Yan Ming; Lee, Jeffrey R.
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5142 - 5143
反应条件
triethylamine in diethyl ether
T=-15 - 20°C; 2 h;
参考文献
JERINI AG
Patent: WO2009/36996 A2, 2009 ;
Location in patent: Page/Page column 77 ;
WO 2009/036996 A2
反应条件
N-bromosuccinmide; copper(I) bromide in acetonitrile
T=80°C; 12 h;
参考文献
Andrade, Leandro H.; Barcellos, Thiago; Santiago, Carolina G.
Tetrahedron Asymmetry, 2010 , vol. 21, # 19 p. 2419 - 2424
反应条件
1: (E)-1-(4-bromophenyl)ethanone O-acetyl oxime With Rh(cod)2SbF6; CyPF-tBu; hydrogen in 1,4-dioxane
T=40°C; P=38002.6 Torr; 24 h; Autoclave;
2: acetic anhydride in 1,4-dioxane
0.5 h; Autoclave; Overall yield = 76 percentSpectr.; enantioselective reaction;
参考文献
Huang, Kexuan; Li, Shengkun; Chang, Mingxin; Zhang, Xumu
Organic Letters, 2013 , vol. 15, # 3 p. 484 - 487
反应条件
1: Et3N / CH2Cl2 / 20 °C
2: 24 percent / DPPP; Et3N / Pd(OAc)2 / dimethylformamide / 100 °C
3: H2 / [(S,S)-Ph-BPE RhCOD]BF4 / methanol / 40 °C / 7500.6 Torr
View Scheme
参考文献
Harrison, Paul; Meek, Graham
Tetrahedron Letters, 2004 , vol. 45, # 50 p. 9277 - 9280
反应条件
1: 24 percent / DPPP; Et3N / Pd(OAc)2 / dimethylformamide / 100 °C
2: H2 / [(S,S)-Ph-BPE RhCOD]BF4 / methanol / 40 °C / 7500.6 Torr
View Scheme
参考文献
Harrison, Paul; Meek, Graham
Tetrahedron Letters, 2004 , vol. 45, # 50 p. 9277 - 9280
反应条件
in dichloromethane
0.5 h; Inert atmosphere;
参考文献
Hou, Guohua; Gosselin, Francis; Li, Wei; McWilliams, J. Christopher; Sun, Yongkui; Weisel, Mark; O'Shea, Paul D.; Chen, Cheng-Yi; Davies, Ian W.; Zhang, Xumu
Journal of the American Chemical Society, 2009 , vol. 131, # 29 p. 9882 - 9883
