2-氨基-1-甲基-1H-咪唑-5-羧酸乙酯合成路线 (共 4 条)
反应条件
1: With potassium tert-butylate in diethyl ether T=0°C; 1.5 h; 2: With hydrogenchloride in diethyl ether; water 0.5 h; 3: With Carbamonitrile in diethyl ether; water T=100°C; 1 h;
参考文献
CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James
Patent: WO2014/18807 A1, 2014 ;
Location in patent: Paragraph 00299; 00300 ;
反应条件
hydrogenchloride; sodium formate; acetic anhydride in formic acid; diethyl ether; water
参考文献
Zeneca Limited
Patent: US5843942 A1, 1998 ;
反应条件
1: C6H8NO4(1-)*Na(1+); ethanol With hydrogenchloride; water T=110°C; 1.5 h; 2: Carbamonitrile With sodium acetate; acetic acid in water T=90 - 100°C; 1.5 h; 3: With hydrogenchloride; potassium carbonate Product distribution / selectivity; more than 3 stages;
参考文献
THRESHOLD PHARMACEUTICALS, INC.
Patent: WO2007/2931 A2, 2007 ;
Location in patent: Page/Page column 141 ;
反应条件
acetic acid; sodium nitrite in water
T=-5 - 20°C;
参考文献
THRESHOLD PHARMACEUTICALS, INC.
Patent: WO2007/2931 A2, 2007 ;
Location in patent: Page/Page column 141-142 ;