2-氨基噁唑-4-甲酸乙酯合成路线 （共 10 条）
反应条件
in ethanol Heating / reflux;
参考文献
Wyeth
Patent: US2009/23707 A1, 2009 ;
Location in patent: Page/Page column 33-34 ;
US 20090023707 A1
反应条件
in ethanol Cyclization; Heating;
参考文献
Synlett, , # 8 p. 1239 - 1240
反应条件
1: With tert.-butylnitrite; copper dichloride in acetonitrile T=60 - 80°C; 2: With hydrogenchloride in dichloromethane; acetonitrile
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
参考文献
ORION CORPORATION; Törmakängas, Olli; Wohlfahrt, Gerd; Salo, Harri; Ramasurbamanian, Rathna Durga; Patra, Pranab Kumar; Martin, Arputharaj Ebenezer; Heikkinen, Terhi; Vesalainen, Anniina; Moilanen, Anu; Karjalainen, Arja
Patent: US2014/94474 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=80°C;
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
反应条件
copper(ll) bromide; isopentyl nitrite in acetonitrile T=60°C;
参考文献
Hall, Adrian; Billinton, Andy; Brown, Susan H.; Chowdhury, Anita; Giblin, Gerard M.P.; Goldsmith, Paul; Hurst, David N.; Naylor, Alan; Patel, Sadhana; Scoccitti, Tiziana; Theobald, Pamela J.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 8 p. 2684 - 2690
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NOSSE, Bernd; FLECK, Martin; ROTH, Gerald Juergen; HEINE, Niklas
Patent: WO2013/98373 A1, 2013 ;
Location in patent: Page/Page column 75 ;
反应条件
1: 83 percent / t-BuONO; CuCl2 / acetonitrile / 2 h / 80 °C
2: 84 percent / Pd(Ph3P)2Cl2 / dioxane / 4 h / 100 °C
View Scheme
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
反应条件
1: 83 percent / t-BuONO; CuCl2 / acetonitrile / 2 h / 80 °C
2: 73 percent / Pd(PPh3)4 / tetrahydrofuran / 4 h / 65 °C
View Scheme
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
反应条件
1.1: tert-butyl nitrite; CuCl2 / acetonitrile / 60 - 80 °C
1.2: 83 percent / conc. HCl / acetonitrile; CH2Cl2
2.1: 87 percent / Pd(PPh3)4; aq. K2CO3 / toluene / 1 h / 90 °C
View Scheme
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 17 p. 2905 - 2907
