1: palladium 10 on activated carbon; hydrogen; triethylamine / methanol / 7 h / 55 °C 2: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 12 h / 20 °C View Scheme

sodium tetrahydroborate in methanol; dichloromethane T=20 - 25°C; 2 h;

palladium 10 on activated carbon; hydrogen; triethylamine in methanol T=55°C; 7 h;

<b>Multi-step reaction with 3 steps<br /> </b>1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / 0 &deg;C / Reflux<br />2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 70 &deg;C / Inert atmosphere<br />3: potassium carbonate / dimethyl sulfoxide / 4 h / 40 - 50 &deg;C<br /> <br /> &nbsp;