7-氟-2,3,4,9-四氢-1H-beta-咔啉合成路线 （共 2 条）
反应条件
1: With hydrogenchloride in water 16 h; Heating / reflux; 2: With potassium carbonate in methanol; water T=20°C; pH=9;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2005/239781 A1, 2005 ;
Location in patent: Page/Page column 87 ;
US 20050239781 A1
反应条件
1: 2-(6-fluoro-1H-indol-3-yl)ethanamine With hydrogenchloride in tetrahydrofuran; ethyl acetate T=20°C; 2: formyl formic acid With potassium hydroxide in water T=80°C; 1.5 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Mitsubishi Pharma Corporation
Patent: EP1714961 A1, 2006 ;
Location in patent: Page/Page column 13-14 ;
