2-(3-溴苯基)-1,3-二氧烷合成路线 （共 39 条）
反应条件
carbon tetrabromide in water; acetonitrile T=45°C; 2 h; sonication;
参考文献
Gregg, Brian T.; Golden, Kathryn C.; Quinn, John F.
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5890 - 5893
反应条件
dihydrogen peroxide; vanadium pentoxide in water T=5°C; 6 h;
参考文献
Gopinath, Rangam; Paital, Alok Ranjan; Patel, Bhisma K
Tetrahedron Letters, 2002 , vol. 43, # 29 p. 5123 - 5126
反应条件
1: N,N-dicyclohexylamine With n-butyllithium in diethyl ether; hexane; toluene T=-20 - 0°C; 0.25 h; 2: 2-(3-bromo-phenyl)-[1,3]-dioxolane With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine
参考文献
Briard, Emmanuelle; Lueoend, Rainer Martin; Machauer, Rainer; Moebitz, Henrik; Rogel, Olivier; Rondeau, Jean-Michel; Rueeger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob
Patent: US2009/54427 A1, 2009 ;
Location in patent: Page/Page column 35 ;
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, form -78 deg C to RT, 2 h 2: m-CPBA / CH2Cl2 / 1.5 h / -78 - 20 °C 3: 1 N HCl / acetonitrile / Ambient temperature View Scheme
参考文献
Ornstein, Paul L.; Bleisch, Thomas J.; Arnold, M. Brian; Kennedy, Joseph H.; Wright, Rebecca A.; Johnson, Bryan G.; Tizzano, Joseph P.; Helton, David R.; Kallman, Mary Jeanne; Schoepp, Darryle D.; Herin, Marc
Journal of Medicinal Chemistry, 1998 , vol. 41, # 3 p. 358 - 378
反应条件
hydrogenchloride; n-butyllithium in tetrahydrofuran; water; acetonitrile
参考文献
Lee, Chih-Hung; Perner, Richard J.; Larson, Daniel P.; Koenig, John R.; Gomtsyan, Arthur R.; Zheng, Guo Zhu; DiDomenico, Stanley; Stewart, Andrew O.; Bayburt, Erol K.
Patent: US2002/173665 A1, 2002 ;
US 20020173665 A1
反应条件
1: 2-(3-bromo-phenyl)-[1,3]-dioxolane With n-butyllithium; lithium chloride in tetrahydrofuran T=-78°C; 1.5 h; 2: cyclopentanone in tetrahydrofuran T=-78 - 20°C; 2 h;
参考文献
Pierre Fabre Medicament
Patent: US2009/82582 A1, 2009 ;
Location in patent: Page/Page column 3 ;
US 20090082582 A1
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane T=-78°C; different reagents and reaction temperature; Product distribution;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=100°C; Buchwald coupling; Inert atmosphere;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 8, p. 841 - 849
反应条件
1: 56 percent / Pd(Pd3P)4 / tetrahydrofuran / 5 h / Heating 2: 91 percent / 1 N HCl / acetonitrile / Ambient temperature View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
hydrogenchloride multistep reaction; various catalysts; Product distribution;
参考文献
Bebon-Rampal, C.; Vanhove, D.
Bulletin de la Societe Chimique de France, 1992 , # 5 p. 501 - 508
