2-(3-溴苯基)-1,3-二氧烷合成路线 （共 39 条）
参考文献
Marx, Thomas; Breitmaier, Eberhard
Liebigs Annalen der Chemie, 1992 , # 3 p. 183 - 186
反应条件
1: 82 percent / Pd(dba)2; (t-Bu)3P / toluene / 8 h / 80 °C
2: 95 percent / aq. acetic acid / 3 h / 50 °C
3: 96 percent / NaBH4 / tetrahydrofuran; methanol
View Scheme
参考文献
Thomas, K. R. Justin; Thompson, Alexis L.; Sivakumar, Aathimanikandan V.; Bardeen, Christopher J.; Thayumanavan
Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 373 - 383
反应条件
magnesium
1.) THF, RT, 1 h, 2.) THF, RT, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sakurai; Ogawa; Suzuki; Kato; Ohashi; Yasuda; Ito
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 765 - 777
反应条件
acetic acid in dichloromethane; water
参考文献
National Research Development Corporation
Patent: US4668701 A1, 1987 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -58 °C
1.2: 1.5 h / -78 - -52 °C
2.1: sodium tetrahydroborate / methanol / 2 h / |Cooling with ice
3.1: hydrogenchloride / methanol; water / 2 h / 20 °C
4.1: N-butylamine / benzene / 1 h / |Reflux
View Scheme
参考文献
Kawazoe, Souichirou; Okamoto, Yoshinori; Yokota, Masaki; Kubota, Hirokazu; Naito, Ryo; Takeuchi, Makoto; Ieda, Shigeru; Okada, Minoru; Oriyama, Takeshi
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 1 p. 127 - 140
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 0.166667 h; Inert atmosphere;
2: With tri-isopropoxy-borane in tetrahydrofuran
T=-78 - 20°C; 1 h; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran
0.5 h;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.; Dreher, Spencer D.; Tudge, Matthew T.
Journal of the American Chemical Society, 2012 , vol. 134, # 28 p. 11667 - 11673
反应条件
1.1: Mg / tetrahydrofuran / 0.5 h / Heating
1.2: 61 percent / tetrahydrofuran / 5 - 40 °C
2.1: 0.74 g / pTsOH / toluene / 16 h / Heating
View Scheme
参考文献
Watkins, Scott E.; Craig, Donald C.; Colbran, Stephen B.
Journal of the Chemical Society, Dalton Transactions, 2002 , # 12 p. 2423 - 2436
反应条件
hydrogenchloride
multistep reaction; various catalysts; Product distribution;
参考文献
Bebon-Rampal, C.; Vanhove, D.
Bulletin de la Societe Chimique de France, 1992 , # 5 p. 501 - 508
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -58 °C
1.2: 1.5 h / -78 - -52 °C
2.1: sodium tetrahydroborate / methanol / 2 h / |Cooling with ice
3.1: hydrogenchloride / methanol; water / 2 h / 20 °C
View Scheme
参考文献
Kawazoe, Souichirou; Okamoto, Yoshinori; Yokota, Masaki; Kubota, Hirokazu; Naito, Ryo; Takeuchi, Makoto; Ieda, Shigeru; Okada, Minoru; Oriyama, Takeshi
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 1 p. 127 - 140
