1: Methyltriphenylphosphonium bromide With sodium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; 2: (S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester in tetrahydrofuran T=-78 - 20°C; 5 h;
参考文献
THERAVANCE, INC.; STANGELAND, Eric L.; VAN ORDEN, Lori Jean; SAITO, Daisuke Roland
Patent: WO2012/75239 A1, 2012 ;
Location in patent: Page/Page column 48-49 ;
Acheson, R. Morrin; Lee, Gary C. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2321 - 2332
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=20°C; 1 h; Inert atmosphere; 2: trans-Boc-4-aminocyclohexanecarbaldehyde in tetrahydrofuran T=20°C; 0.5 h; 3: With sodium hydrogen sulphate; water in tetrahydrofuran
