4-溴-3-氧代-丁酸甲酯合成路线 （共 15 条）
反应条件
sodium hydride in tetrahydrofuran; hexane
T=20°C;
参考文献
Zheng, Shi-Long; Yu, Wing-Yiu; Che, Chi-Ming
Organic Letters, 2002 , vol. 4, # 6 p. 889 - 892
反应条件
1: 72 percent / p-toluenesulfonic acid / 4 h / Heating
2: NaI / acetone / 2.5 h / Ambient temperature
3: AgNO2, quartz sand / diethyl ether / 108 h
4: KOCH3, urea / methanol / 0.08 h / 0 °C
View Scheme
参考文献
Duthaler, Rudolf O.
Helvetica Chimica Acta, 1983 , vol. 66, # 5 p. 1475 - 1492
反应条件
1: 55 percent / 1,2-dimethoxy-ethane / 2 h / 85 °C
2: 92 percent / NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature
View Scheme
参考文献
Goorbergh, J. A. M. van den; Gen, A. van der
Recueil: Journal of the Royal Netherlands Chemical Society, 1983 , vol. 102, # 9 p. 393 - 399
反应条件
D-glucose in acetic acid n-butyl ester
T=30°C; 4 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Asako, Hiroyuki; Shimizu, Masatoshi; Makino, Yoshihide; Itoh, Nobuya
Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2664 - 2666
反应条件
sodium hydride in tetrahydrofuran; hexane
T=20°C;
参考文献
Zheng, Shi-Long; Yu, Wing-Yiu; Che, Chi-Ming
Organic Letters, 2002 , vol. 4, # 6 p. 889 - 892
