1,4-哌啶二羧酸 1-(1,1-二甲基乙基) 4-(苯基甲基)酯合成路线 （共 6 条）
反应条件
potassium carbonate in acetone 2 h; Heating / reflux;
参考文献
TORAY INDUSTRIES, INC.
Patent: EP2009006 A1, 2008 ;
Location in patent: Page/Page column 78 ;
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With caesium carbonate in methanol T=20°C; 2 h; 2: benzyl bromide in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
CEPHALON, INC.; SEDE SECONDARIA DELLA CELL THERAPEUTICS, INC.
Patent: WO2005/21558 A2, 2005 ;
Location in patent: Page/Page column 226 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 10 p. 1289 - 1292
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=0 - 20°C; 24 h;
参考文献
US2008/275085 A1, ;
Page/Page column 31 ;
US 20080275085 A1
反应条件
4-(N,N-dimethlyamino)pyridine; 1,2-dichloro-ethane; benzyl alcohol; Nalco silica sol 1060 in dichloromethane; ethyl acetate
参考文献
US5891889 A1, ;
US 5891889 A
反应条件
trifluoroacetic acid in dichloromethane
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/71730 A1, 2006 ;
Location in patent: Page/Page column 254; 255 ;
WO 2006/071730 A1
