1,2,3,4-四氢-2-甲基喹啉合成路线 （共 73 条）
反应条件
1: polyphosphoric acid / 6 h / 110 °C 2: Et3SiH, BF3-OEt2 / CH2Cl2 / 24 h / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 7 p. 1008 - 1012
反应条件
hydrogen; nickel T=200°C; P=7600 Torr; or Ru/C, 100 atm, 150 deg C; Equilibrium constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 11 p. 3167 - 3174
反应条件
1: 82 percent / pyridine-borane / ethanol / below 5 deg C 2: 57 percent / AlCl3(3eq.) / CH2Cl2 / 6 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 6 p. 1615 - 1623
反应条件
1: 94 percent / pyridine-borane / ethanol / below 5 deg C 2: 48 percent / AlCl3(3eq.) / CH2Cl2 / 6 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 6 p. 1615 - 1623
反应条件
1: 52 percent / pyridine-borane / ethanol / below 5 deg C 2: 24 percent / AlCl3(3eq.) / CH2Cl2 / 6 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 6 p. 1615 - 1623
反应条件
methanol; hydrogenchloride
参考文献
Canadian Journal of Chemistry, , vol. 63, p. 412 - 417
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 35 °C / Inert atmosphere 2.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2.2: pH 8 / Saturated solution 3.1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine; (R)-Segphos® / isopropyl alcohol; toluene / 17 h / 20 °C / 22502.3 Torr / Autoclave View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4747 - 4750
反应条件
1.1: Irradiation 2.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 35 °C / Inert atmosphere 3.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 3.2: pH 8 / Saturated solution 4.1: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine; (R)-Segphos® / isopropyl alcohol; toluene / 17 h / 20 °C / 22502.3 Torr / Autoclave View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4747 - 4750
反应条件
1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 - 35 °C 2: phosphorus tribromide / dichloromethane / 0 - 20 °C 3: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-Segphos®; hydrogen; iodine / toluene; isopropyl alcohol / 17 h / 20 °C / 37503.8 Torr / |Autoclave View Scheme
参考文献
Tetrahedron, , vol. 69, # 44 p. 9322 - 9328
反应条件
1: phosphorus tribromide / dichloromethane / 0 - 20 °C 2: di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-Segphos®; hydrogen; iodine / toluene; isopropyl alcohol / 17 h / 20 °C / 37503.8 Torr / |Autoclave View Scheme
参考文献
Tetrahedron, , vol. 69, # 44 p. 9322 - 9328
