2,4-二氯-5,6-二甲基嘧啶合成路线 （共 14 条）
反应条件
trichlorophosphate 4 h; Reflux;
参考文献
Martic, Miljen; Pernot, Lucile; Westermaier, Yvonne; Perozzo, Remo; Kraljevic, Tatjana Gazivoda; Kristafor, Svjetlana; Raic-Malic, Silvana; Scapozza, Leonardo; Ametamey, Simon
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 4 p. 293 - 315
反应条件
in trichlorophosphate T=125°C; 3 h; Heating / reflux;
参考文献
Taisho Pharmaceutical Co. Ltd.; Arena Pharmaceuticals, Inc.
Patent: EP1464335 A2, 2004 ;
Location in patent: Page/Page column 318 ;
EP 1464335 A2
反应条件
1: potassium tert-butylate / ethanol / 0.25 h / |Reflux 2: chloroacetic acid; water / |Reflux 3: trichlorophosphate; N,N-dimethyl-formamide / |Reflux; |Inert atmosphere View Scheme
反应条件
1: chloroacetic acid; water / |Reflux 2: trichlorophosphate; N,N-dimethyl-formamide / |Reflux; |Inert atmosphere View Scheme
参考文献
Chemische Berichte, , vol. 34, p. 2813
反应条件
phosphorus; hydrogen iodide
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
反应条件
ethanol; ammonia T=100°C; im Rohr;
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
反应条件
1: alcohol; ammonia / 100 °C / im Rohr 2: zinc dust; water View Scheme
参考文献
Schlenker
Chemische Berichte, 1901 , vol. 34, p. 2813
参考文献
Martic, Miljen; Pernot, Lucile; Westermaier, Yvonne; Perozzo, Remo; Kraljevic, Tatjana Gazivoda; Kristafor, Svjetlana; Raic-Malic, Silvana; Scapozza, Leonardo; Ametamey, Simon
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 4 p. 293 - 315
