5-溴-2-甲基吲哚-3-羧醛合成路线 （共 5 条）
反应条件
N-bromosuccinmide in dichloromethane 0.25 h;
参考文献
Jong, Ling; Chao, Wan-Ru
Patent: US2004/43965 A1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
1: With trichlorophosphate T=20°C; 2: With sodium hydroxide 2 h;
参考文献
Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; De Sousa, Rodolphe Alves; Larue, Valery; Cresteil, Thierry; Dardel, Frederic; Artaud, Isabelle; Meinnel, Thierry
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 10 - 20
反应条件
pyridine; hydroxylamine hydrochloride
T=20°C; 5 h;
参考文献
Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; De Sousa, Rodolphe Alves; Larue, Valery; Cresteil, Thierry; Dardel, Frederic; Artaud, Isabelle; Meinnel, Thierry
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 10 - 20
反应条件
1: 5-bromo-2-methyl-1H-indole-3-carbaldehyde With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: benzenesulfonyl chloride in tetrahydrofuran
T=20°C;
参考文献
Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; De Sousa, Rodolphe Alves; Larue, Valery; Cresteil, Thierry; Dardel, Frederic; Artaud, Isabelle; Meinnel, Thierry
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 10 - 20
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 0 °C
1.2: 95 percent / tetrahydrofuran / 20 °C
2.1: 100 percent / NaBH4 / methanol / 6 h / 20 °C
View Scheme
参考文献
Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; De Sousa, Rodolphe Alves; Larue, Valery; Cresteil, Thierry; Dardel, Frederic; Artaud, Isabelle; Meinnel, Thierry
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 10 - 20
