1-甲基-1H-吡唑-5-羧酸甲酯合成路线 （共 6 条）
反应条件
in methanol; toluene 1 h;
参考文献
PFIZER INC.
Patent: WO2006/43145 A1, 2006 ;
Location in patent: Page/Page column 120 ;
WO 2006/043145 A1
参考文献
Vasilevskii, S. F.; Shvartsberg, M. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 5 p. 1071 - 1077
反应条件
in diethyl ether; chloroform Title compound not separated from byproducts;
参考文献
Parameswaran; Naik; Govenkar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 5 p. 1093 - 1096
反应条件
ammonia in water 16 h;
参考文献
PFIZER INC.
Patent: WO2006/43145 A1, 2006 ;
Location in patent: Page/Page column 120 ;
WO 2006/043145 A1
反应条件
sulfuric acid; iodine; iodic acid in tetrachloromethane; acetic acid T=80°C; 0.5 h;
参考文献
Vasilevskii, S. F.; Shvartsberg, M. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 5 p. 1071 - 1077
反应条件
1: 80 percent / cc. aq. ammonium hydroxide / Ambient temperature
2: 82 percent / phosphoryl chloride / pyridine / 2 h / -5 °C
View Scheme
参考文献
Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; Mendoza, Javier de; Martin, M. Rosario
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1209 - 1216
