1-甲基-1H-吡唑-3-羧酸甲酯合成路线 （共 10 条）
反应条件
toluene-4-sulfonic acid in dichloromethane T=-20°C;
参考文献
Canadian Journal of Chemistry, , vol. 72, # 12 p. 2458 - 2467
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 5 p. 1071 - 1077
反应条件
1: potassium permanganate, potassium hydroxide / H2O / 2 h / 100 °C 2: 0.9 mg / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Antibiotics, , vol. 48, # 11 p. 1336 - 1344
反应条件
in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
Journal of Antibiotics, , vol. 48, # 11 p. 1336 - 1344
反应条件
in benzene-d6 48 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Canadian Journal of Chemistry, , vol. 72, # 12 p. 2458 - 2467
反应条件
sodium hydroxide in tetrahydrofuran T=50°C; 2 h;
参考文献
Broom; Elder; Hannan; Pons; O'Hanlon; Walker; Wilson; Woodall
Journal of Antibiotics, 1995 , vol. 48, # 11 p. 1336 - 1344
反应条件
1: 86 percent / cc. aq. ammonium hydroxide / Ambient temperature 2: 85 percent / phosphoryl chloride / pyridine / 2 h / -5 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1209 - 1216
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 18 h;
参考文献
WO2014/66795 A1, ;
Paragraph 0175 ;
反应条件
sulfuric acid; iodine; iodic acid in tetrachloromethane; acetic acid
T=80°C; 0.5 h;
参考文献
Vasilevskii, S. F.; Shvartsberg, M. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 5 p. 778 - 784
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 5 p. 1071 - 1077
反应条件
ammonium hydroxide
Ambient temperature;
参考文献
Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; Mendoza, Javier de; Martin, M. Rosario
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1209 - 1216
