2-羟基-3-甲氧基-3,3-二苯基丙酸甲酯合成路线 （共 10 条）
反应条件
boron trifluoride diethyl etherate T=0°C; 0.333333 h;
参考文献
Riechers, Hartmut; Albrecht, Hans-Peter; Amberg, Willi; Baumann, Ernst; Bernard, Harald; Boehm, Hans-Joachim; Klinge, Dagmar; Kling, Andreas; Mueller, Stefan; Raschack, Manfred; Unger, Liliane; Walker, Nigel; Wernet, Wolfgang
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2123 - 2128
反应条件
boron trifluoride-diethyl ether complex in methanol; ethyl acetate
反应条件
1: With sodium methylate in tetrahydrofuran T=-10 - -4°C; 2 h; 2: With methanol; toluene-4-sulfonic acid T=0 - 35°C; 2.75 h;
参考文献
US2011/263854 A1, ;
Page/Page column 7-8 ;
US 20110263854 A1
反应条件
1: 89 percent / NaOMe / tetrahydrofuran / 0.5 h / 0 °C 2: 98 percent / BF3*Et2O / 0.33 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 11 p. 2123 - 2128
反应条件
1.1: sodium hydroxide; water / 2 h / 95 - 100 °C 1.2: 40 - 45 °C / pH 1.3 2.1: sodium methylate; (S)-2-carbomethoxypyrrolidine hydrochloride / tert-butyl methyl ether; methanol / 1.25 h / 25 - 60 °C / Reflux 3.1: toluene-4-sulfonic acid / 48 h / 25 - 35 °C 4.1: potassium carbonate / acetone / 0.67 h / 25 - 35 °C 4.2: 10 h / 55 - 60 °C 5.1: sodium hydroxide / water; methanol / 3 h / 25 - 60 °C 5.2: pH 5.8 View Scheme
参考文献
Jansen; Knopp; Amberg; Bernard; Koser; Mueller; Muenster; Pfeiffer; Riechers
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 16 - 22
反应条件
1.1: sodium hydroxide; water / 2 h / 95 - 100 °C 1.2: 40 - 45 °C / pH 1.3 2.1: sodium methylate; (S)-2-carbomethoxypyrrolidine hydrochloride / tert-butyl methyl ether; methanol / 1.25 h / 25 - 60 °C / Reflux View Scheme
参考文献
Reddy, Manne Satyanarayana; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda
Patent: US2011/263854 A1, 2011 ;
US 20110263854 A1
反应条件
1.1: sodium hydroxide; water / 2 h / 95 - 100 °C 1.2: 40 - 45 °C / pH 1.3 2.1: sodium methylate; (S)-2-carbomethoxypyrrolidine hydrochloride / tert-butyl methyl ether; methanol / 1.25 h / 25 - 60 °C / Reflux 3.1: toluene-4-sulfonic acid / 48 h / 25 - 35 °C View Scheme
参考文献
CIPLA LIMITED; KING, Lawrence; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; NAIK, Sanjay; GHAGARE, Maruti; CHIKHALIKAR, Sandip Vasant
Patent: WO2013/57468 A1, 2013 ;
反应条件
1: 2-hydroxy methyl 3-methoxy-3,3-diphenylpropionate With [Cu(S,S)-t-Bu-box]OTf2 in dichloromethane T=0°C; 0.166667 h; Inert atmosphere; 2: 1-isocyanatopropane in dichloromethane T=0°C; 3 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Kurono, Nobuhito; Ohtsuga, Kentaro; Wakabayashi, Masanori; Kondo, Tadahiro; Ooka, Hirohito; Ohkuma, Takeshi
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10312 - 10318
反应条件
water; sodium hydroxide T=90 - 95°C; 1.5 h;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala; ADIBHATLA, Kali Satya Bhujanga Rao; BALINA, Veera Swamy; KASA, Srinivasu; NANNAPANENI, Venkaiah Chowdary
Patent: WO2012/17441 A1, 2012 ;
Location in patent: Page/Page column 11 ;
反应条件
1.1: sodium hydroxide; water / 2 h / 95 - 100 °C
1.2: 40 - 45 °C / pH 1.3
2.1: sodium methylate; (S)-2-carbomethoxypyrrolidine hydrochloride / tert-butyl methyl ether; methanol / 1.25 h / 25 - 60 °C / Reflux
3.1: toluene-4-sulfonic acid / 48 h / 25 - 35 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 25 - 35 °C
4.2: 4 h / 90 - 95 °C
View Scheme
参考文献
CIPLA LIMITED; KING, Lawrence; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; NAIK, Sanjay; GHAGARE, Maruti; CHIKHALIKAR, Sandip Vasant
Patent: WO2013/57468 A1, 2013 ;
