1,4-二氯二氮杂萘-6-甲腈合成路线 （共 7 条）
反应条件
thionyl chloride; trichlorophosphate Heating;
参考文献
Eisai Co., Ltd.
Patent: US5849741 A1, 1998 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate in dichloromethane; trichlorophosphate
参考文献
Eisai Co., Ltd.
Patent: US5849741 A1, 1998 ;
反应条件
1: 1.) conc. HCl, NaNO2, 2.) CuCl / 1.) H2O, -20 deg C, 2.) H2o, toluene, -20 deg C, 2 h 2: 82 percent / hydrazine monohydrate / ethanol / 5 h / Ambient temperature 3: POCl3, i-PrEtN / 3 h / Heating View Scheme
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
反应条件
1: 82 percent / hydrazine monohydrate / ethanol / 5 h / Ambient temperature 2: POCl3, i-PrEtN / 3 h / Heating View Scheme
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
反应条件
i-PrEtN; trichlorophosphate 3 h; Heating;
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
反应条件
1: 94 percent / NH2-NH2*H2O, NMP / 0.5 h / Ambient temperature 2: 70 percent / POCl3, SOCl2 / Heating View Scheme
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
反应条件
1: 1.) 20percent aq. NH3, 2.) NMP / 1.) acetone, 1 h, 2.) 150 deg C, 3 h 2: 94 percent / NH2-NH2*H2O, NMP / 0.5 h / Ambient temperature 3: 70 percent / POCl3, SOCl2 / Heating View Scheme
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
