乙基-4,4-二氟环己烷羧酸盐合成路线 （共 15 条）
反应条件
Fluolead; ethanol in dichloromethane T=20°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 51 p. 18199 - 18205
反应条件
diethylamino-sulfur trifluoride in tetrachloromethane T=0 - 20°C; 16 h;
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
Location in patent: Paragraph 00312 ;
WO 2013/013188 A1
反应条件
hydrogen fluoride; antimony(V) pentachloride T=14 - 50°C; P=1125.11 - 4500.45 Torr; 3.5 h;
参考文献
EP1364938 A1, ;
Page/Page column 8 ;
反应条件
1: With pyridine; hydrogen fluoride; NOBF4 T=0°C; 2: ethyl 4-(hydroxyimino)cyclohexanecarboxylate T=-7 - 27°C; 5 h; Product distribution / selectivity;
参考文献
HONEYWELL SPECIALTY CHEMICALS SEELZE GMBH
Patent: WO2005/14519 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogen fluoride T=20°C; Product distribution / selectivity;
参考文献
SOLVAY (Societe Anonyme)
Patent: EP1985603 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen fluoride T=-30 - 90°C; 0.683333 - 22.2833 h; Conversion of starting material;
参考文献
EP1985603 A1, ;
Page/Page column 6-8 ;
反应条件
hydrogen fluoride; sodium nitrite T=-10 - 2°C; 2 h; Product distribution / selectivity;
参考文献
WO2005/14519 A1, ;
Page/Page column 8 ;
反应条件
1.1: sodium hydroxide; ethanol / 18 h / 0 - 20 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -70 °C 2.2: 0 °C 3.1: lithium borohydride / tetrahydrofuran / |Inert atmosphere View Scheme
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
WO 2013/013188 A1
反应条件
1: 65 percent / NaOH / tetrahydrofuran; H2O 2: 49 percent / polimer bound carbodiimide / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
ethanol; sodium hydroxide T=0 - 20°C; 18 h;
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
Location in patent: Paragraph 00313; 00314 ;
WO 2013/013188 A1
