3-(3,4-二甲氧基苯基)-1-(3-羟基苯基)-1-丙酮合成路线 （共 6 条）
反应条件
ammonium formate; 5 palladium on charcoal in methanol T=55°C; 3.5 h; Inert atmosphere;
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
potassium carbonate in acetone T=20°C; Alkylation; 20 h;
参考文献
Keenan, Terence; Yaeger, David R.; Courage, Nancy L.; Rollins, Carl T.; Pavone, Mary Ellen; Rivera, Victor M.; Yang, Wu; Guo, Tao; Amara, Jane F.; Clackson, Tim; Gilman, Michael; Holt, Dennis A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1309 - 1335
反应条件
1: 99 percent / K2CO3 / acetone / 20 h / 20 °C 2: 98 percent / (+)-DIP-chloride / tetrahydrofuran / -20 °C View Scheme
参考文献
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.; Gopalakrishnan, Ranganath; Hausch, Felix
Patent: EP2607352 A1, 2013 ;
反应条件
1: potassium carbonate / acetone / 20 h / 20 °C 2: potassium carbonate; hydrogen / 144 h / 11251.1 Torr View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.; GOPALAKRISHNAN, Ranganath; HAUSCH, Felix
Patent: WO2013/91900 A1, 2013 ;
