1,1-二甲基乙基 [3-[3-(3,4-二甲氧基苯基)-1-氧代-丙基]苯氧基]-乙酸酯合成路线 （共 6 条）
反应条件
potassium carbonate in acetone T=20°C; Alkylation; 20 h;
参考文献
Keenan, Terence; Yaeger, David R.; Courage, Nancy L.; Rollins, Carl T.; Pavone, Mary Ellen; Rivera, Victor M.; Yang, Wu; Guo, Tao; Amara, Jane F.; Clackson, Tim; Gilman, Michael; Holt, Dennis A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1309 - 1335
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr 3: 99 percent / K2CO3 / acetone / 20 h / 20 °C View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
1: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr 2: 99 percent / K2CO3 / acetone / 20 h / 20 °C View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
1: 91 percent / aq. KOH / ethanol / 16 h / 20 °C 2: 76 percent / H2 / Lindlar catalyst / aq. methanol / 6 h / 2068.59 - 2585.74 Torr 3: 99 percent / K2CO3 / acetone / 20 h / 20 °C View Scheme
参考文献
ARIAD PHARMACEUTICALS, INCORPORATED; LI, Feng; WANG, Yihan
Patent: WO2012/103279 A2, 2012 ;
反应条件
bis[(1S,2R,3S,5S)-pinan-3-yl]chloroborane in tetrahydrofuran T=-20°C; Reduction;
参考文献
Keenan, Terence; Yaeger, David R.; Courage, Nancy L.; Rollins, Carl T.; Pavone, Mary Ellen; Rivera, Victor M.; Yang, Wu; Guo, Tao; Amara, Jane F.; Clackson, Tim; Gilman, Michael; Holt, Dennis A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1309 - 1335
反应条件
in tetrahydrofuran; diethyl ether; (+/-)-Tetrahydropapaveroline
参考文献
Ariad Pharmaceuticals, Inc.
Patent: US6150527 A1, 2000 ;
