3-溴-5-氟-2-羟基苯甲醛合成路线 （共 4 条）
反应条件
triethylamine; magnesium chloride in tetrahydrofuran T=160°C; 0.25 h; Microwave irradiation;
参考文献
Infinity Discovery, Inc.
Patent: US2008/114167 A1, 2008 ;
Location in patent: Page/Page column 184 ;
US 20080114167 A1
反应条件
1: With trifluoroacetic acid 18 h; Reflux; 2: With sulfuric acid; water T=20°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: US2010/331341 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
N-bromosuccinmide in DMF (N,N-dimethyl-formamide) T=20°C; 5 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/50637 A2, 2004 ;
Location in patent: Page 70 ;
WO 2004/050637 A2
反应条件
1: With potassium carbonate; tetra-(n-butyl)ammonium iodide
T=130°C; 4 h;
2: With potassium hydroxide in tetrahydrofuran; water
T=0 - 20°C; 18 h;
3: With hydrogenchloride in water
参考文献
ASTRAZENECA AB
Patent: US2010/331341 A1, 2010 ;
Location in patent: Page/Page column 32 ;
