1,4-二(2-氯乙氧基)-2,5-二溴苯合成路线 （共 6 条）
反应条件
bromine; iron in tetrachloromethane 4.5 h; Ambient temperature;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
1: 88 percent / SOCl2; pyridine / 20 °C 2: 91 percent / Br2; ZnCl2 / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 6 p. 1003 - 1010
反应条件
1: 32 percent / K2CO3 / acetone / 24 h / Heating 2: 92 percent / Fe, Br2 / CCl4 / 4.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 15 p. 2953 - 2961
反应条件
1: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating 2: AlCl3 / CH2Cl2 / 16 h 3: 92 percent / TFA; Et3SiH / 6 h / Heating 4: 64 percent / DDQ / dioxane / 24 h / Heating View Scheme
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
1: 80 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h 2: 71 percent / SnCl4 / CH2Cl2 / 0.5 h View Scheme
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
n-butyllithium in tetrahydrofuran; hexane
0.166667 h;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
