(2-溴-1-氟)乙基苯合成路线 （共 12 条）
反应条件
N-bromosuccinmide; triethylamine-3HF in dichloromethane Fluorination; Bromination;
参考文献
Meyer; Froehlich; Haufe
Synthesis, 2000 , # 10 p. 1479 - 1490
反应条件
N-bromosuccinmide; TBAF*HF in dichloromethane 19 h; Ambient temperature;
参考文献
Camps, F.; Chamorro, E.; Gasol, V.; Guerrero, A.
Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4294 - 4298
反应条件
methyl hypobromite; boron trifluoride diethyl etherate in dichloromethane T=25°C; 0.0833333 h; Yield given;
参考文献
Heasley, Victor L.; Gipe, Robert K.; Martin, Jody L.; Wiese, Harry C.; Oakes, Melanie L.; Shellhamer, Dale F.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3195 - 3199
反应条件
N-bromosuccinmide; n-Bu4NH2F3 in dichloromethane 2 h; Heating;
参考文献
Albanese, Domenico; Landini, Dario; Penso, Michele; Pratelli, Marco
Gazzetta Chimica Italiana, 1991 , vol. 121, # 12 p. 537 - 541
反应条件
boron trifluoride diethyl etherate in dichloromethane T=25°C; 0.0833333 h; Yield given;
参考文献
Heasley, Victor L.; Gipe, Robert K.; Martin, Jody L.; Wiese, Harry C.; Oakes, Melanie L.; Shellhamer, Dale F.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3195 - 3199
反应条件
boron trifluoride diethyl etherate; N-Bromoethylamine in dichloromethane Ambient temperature;
参考文献
Heasley, Gene E.; Janes, J. Mark; Stark, Stephen R.; Robinson, Brian L.; Heasley, Victor L.; Shellhamer, Dale F.
Tetrahedron Letters, 1985 , vol. 26, # 15 p. 1811 - 1814
反应条件
boron trifluoride diethyl etherate in dichloromethane Ambient temperature;
参考文献
Heasley, Gene E.; Janes, J. Mark; Stark, Stephen R.; Robinson, Brian L.; Heasley, Victor L.; Shellhamer, Dale F.
Tetrahedron Letters, 1985 , vol. 26, # 15 p. 1811 - 1814
反应条件
pyridine; phosphorus tribromide
参考文献
Aranda,G.
Chimica Therapeutica, 1971 , vol. 6, p. 262 - 267
反应条件
1: 81 percent / t-BuOK / tetrahydrofuran / 2 h / 25 °C 2: 91 percent / Et3N*3HF; N-bromosuccinimide / CH2Cl2 / 25 °C View Scheme
参考文献
Oldendorf, Jens; Haufe, Guenter
Advanced Synthesis and Catalysis, 2000 , vol. 342, # 1 p. 52 - 57
反应条件
potassium tert-butylate in pentane
T=0°C; 1 h; Reflux;
参考文献
ORYZON GENOMICS, S.A.; ORTEGA MUÑOZ, Alberto; FYFE, Mathew Colin Thor; MARTINELL PEDEMONTE, Marc; ESTIARTE MARTÍNEZ, María de los Ángeles; VALLS VIDAL, Nuria; KURZ, Guido; CASTRO PALOMINO LARIA, Julio Cesar
Patent: WO2013/57322 A1, 2013 ;
Location in patent: Page/Page column 149; 150 ;
