反应条件
Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '1746607', constants.ctx, '0')">methyl 2-hydroxy-2-methylpropionate</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a>; <a href="#" onclick="return RXDsubstances(event, this, '8190416', constants.ctx, '0')">mineral oil</a> <br />T=0 - 20°C; 1 h; Inert atmosphere; <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '505934', constants.ctx, '0')">ethyl iodide</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a>; <a href="#" onclick="return RXDsubstances(event, this, '8190416', constants.ctx, '0')">mineral oil</a> <br />T=0°C; <br /> <br />
参考文献
Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Caldwell, Timothy Malcolm; Kaufman, Michael D.; Patt, William C.; Samarakoon, Thiwanka; Vogeti, Lakshminarayana; Yates, Karen M. Patent: US2014/275080 A1, 2014 ; Location in patent: Paragraph 0387 ;
