外消旋-N-[2-(2,3-二氢-6-甲氧基-1H-茚-1-基)乙基]丙酰胺合成路线 （共 6 条）
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235789 B1, 2001 ;
反应条件
1.1: NaH / tetrahydrofuran / 20 °C 1.2: tetrahydrofuran / 20 °C 2.1: H2; ethanolic NH3 / Raney-nickel / 40 °C / 3600.36 Torr 3.1: Et3N / tetrahydrofuran View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
反应条件
1: H2; ethanolic NH3 / Raney-nickel / 40 °C / 3600.36 Torr 2: Et3N / tetrahydrofuran View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
反应条件
sodium hydroxide in tetrahydrofuran T=0°C; Schotten-Baumann acylation;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
Corynebacterium ammoniagenes IFO12612 in methanol T=37°C; 24 h;
参考文献
Tarui, Naoki; Watanabe, Hayao; Fukatsu, Kohji; Ohkawa, Shigenori; Nakahama, Kazuo
Bioscience, Biotechnology and Biochemistry, 2002 , vol. 66, # 2 p. 464 - 466
反应条件
Corynebacterium ammoniagenes IFO12612 in methanol T=37°C; 24 h;
参考文献
Tarui, Naoki; Watanabe, Hayao; Fukatsu, Kohji; Ohkawa, Shigenori; Nakahama, Kazuo
Bioscience, Biotechnology and Biochemistry, 2002 , vol. 66, # 2 p. 464 - 466
