(S)-N-[2-(2,3-二氢-6-甲氧基-1H-茚-1-基)乙基]丙酰胺合成路线 （共 29 条）
反应条件
hydrogen; Ru(OCOCH3)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) in methanol T=70°C; P=68255.5 Torr; 3 h;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
hydrogen; Ru(OCOCH3)2[(S)-BINAP] in methanol T=70°C; P=68404.6 Torr; 3 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1199304 A1, 2002 ;
Location in patent: Referential example 29 ;
EP 1199304 A1
反应条件
in methanol; hydrogen
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6034239 A1, 2000 ;
US 6034239 A
反应条件
hydrogen; Ru(OCOCH3)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) in methanol T=70°C; P=68255.5 Torr; Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4212 - 4221
反应条件
Ru(OCOCH3)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl); hydrogen in methanol T=70°C; P=67505.4 Torr; 1 h;
参考文献
Yamano, Toru; Yamashita, Masayuki; Adachi, Mari; Tanaka, Mitsutaka; Matsumoto, Kiyoharu; Kawada, Mitsuru; Uchikawa, Osamu; Fukatsu, Kohji; Ohkawa, Shigenori
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 184 - 190
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 1 h; optical yield given as percent ee;
参考文献
Zhang, Xuan; Yuan, Wei; Luo, Yu; Huang, Qing-Qing; Lu, Wei
Heterocycles, 2012 , vol. 85, # 1 p. 73 - 84
反应条件
1.1: NaH / tetrahydrofuran / 20 °C 1.2: tetrahydrofuran / 20 °C 2.1: H2; ethanolic NH3 / Raney-Co 3.1: Et3N / tetrahydrofuran / 0 °C 4.1: H2; Ru(OAc)2[(S)-binap] / methanol / 70 °C / 68256.8 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4222 - 4239
反应条件
1: H2; ethanolic NH3 / Raney-Co 2: Et3N / tetrahydrofuran / 0 °C 3: H2; Ru(OAc)2[(S)-binap] / methanol / 70 °C / 68256.8 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4222 - 4239
反应条件
1: Et3N / tetrahydrofuran / 0 °C 2: H2; Ru(OAc)2[(S)-binap] / methanol / 70 °C / 68256.8 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4222 - 4239
反应条件
1: H2; NH3 / Raney-cobalt / ethanol / 40 °C / 3000.24 Torr 2: Et3N / tetrahydrofuran / 0 °C 3: H2 / Ru(OCOCH3)2[(S)-BINAP] / methanol / 70 °C / 68255.5 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 19 p. 4212 - 4221
