4-[(S)-[(2S,5R)-2,5-二甲基-4-(2-丙烯-1-基)-1-哌嗪基]苯基甲基]-N,N-二乙基苯甲酰胺合成路线 （共 5 条）
反应条件
potassium carbonate in acetonitrile 72 h; Heating;
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
反应条件
1: SOCl2 / benzene / 3 h / Heating 2: CHCl3 / 4 h / Ambient temperature 3: 81 percent / NaBH4 / ethanol; H2O / 2 h / Heating 4: 94 percent / 37percent aq. HCl / CHCl3 / Ambient temperature 5: 22 percent / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
反应条件
1: 81 percent / NaBH4 / ethanol; H2O / 2 h / Heating 2: 94 percent / 37percent aq. HCl / CHCl3 / Ambient temperature 3: 22 percent / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
反应条件
1: 94 percent / 37percent aq. HCl / CHCl3 / Ambient temperature 2: 22 percent / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
反应条件
1: 39.65 g / ethanol / Ambient temperature 3: 22 percent / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704
