4-(苯并[d]噻唑)-2-溴苯胺合成路线 （共 6 条）
反应条件
sodium perborate; acetic acid; potassium bromide T=20°C; 22 h;
参考文献
Karlsson, H. Jonas; Bergqvist, Mattias H.; Lincoln, Per; Westman, Gunnar
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2369 - 2384
反应条件
1: 57 percent / PPA / 4 h / 220 °C 2: 79 percent / Br2 / CH2Cl2 / 0.03 h / -5 °C View Scheme
参考文献
Chua, Mei-Sze; Shi, Dong-Fang; Wrigley, Samantha; Bradshaw, Tracey D.; Hutchinson, Ian; Shaw, P. Nicholas; Barrett, David A.; Stanley, Lesley A.; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 381 - 392
反应条件
1: polyphosphoric acid / 220 °C 2: Br2 / CH2Cl2 / -5 °C View Scheme
参考文献
Shi, Dong-Fang; Bradshaw, Tracey D.; Wrigley, Samantha; McCall, Carol J.; Lelieveld, Peter; Fichtner, Iduna; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3375 - 3384
反应条件
1: 85 percent / 2,4-bis(4-methoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane / hexamethylphosphoric acid triamide / 6 h / 100 °C 2: 90 percent / SnCl2*2H2O / ethanol / 4 h / Heating 3: 79 percent / Br2 / CH2Cl2 / 0.03 h / -5 °C View Scheme
参考文献
Shi, Dong-Fang; Bradshaw, Tracey D.; Wrigley, Samantha; McCall, Carol J.; Lelieveld, Peter; Fichtner, Iduna; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3375 - 3384
反应条件
1: 90 percent / SnCl2*2H2O / ethanol / 4 h / Heating 2: 79 percent / Br2 / CH2Cl2 / 0.03 h / -5 °C View Scheme
参考文献
Shi, Dong-Fang; Bradshaw, Tracey D.; Wrigley, Samantha; McCall, Carol J.; Lelieveld, Peter; Fichtner, Iduna; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3375 - 3384
反应条件
1: 74 percent / pyridine 2: 90 percent / SnCl2*2H2O / ethanol / 4 h / Heating 3: 79 percent / Br2 / CH2Cl2 / 0.03 h / -5 °C View Scheme
参考文献
Shi, Dong-Fang; Bradshaw, Tracey D.; Wrigley, Samantha; McCall, Carol J.; Lelieveld, Peter; Fichtner, Iduna; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3375 - 3384
