5-溴-6-氨基吡啶-2-羧酸甲酯合成路线 （共 18 条）
反应条件
1: hydrogenchloride / methanol / 18 h / Reflux 2: bromine / chloroform / 40 h / 20 °C View Scheme
参考文献
US2011/201605 A1, ;
WO2011/101304 A2, ;
WO 2011/101304 A2
反应条件
1: sulfuric acid / Reflux 2: bromine / chloroform / 20 °C View Scheme
参考文献
US2011/152312 A1, ;
WO2011/75591 A1, ;
反应条件
sulfuric acid 24 h; Reflux;
参考文献
Fray, M. Jonathan; Gillmore, Adam T.; Glossop, Melanie S.; McManus, David J.; Moses, Ian B.; Praquin, Celine F.B.; Reeves, Keith A.; Thompson, Lisa R.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 263 - 271
反应条件
sulfuric acid; sodium nitrite in water T=0°C; 0.25 h;
参考文献
Kelly, T. Ross; Lang, Fengrui
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4623 - 4633
反应条件
1: mercapto acetic acid ethylester With sodium hydride in N,N-dimethyl-formamide
T=0°C; 1 h;
2: methyl 6-amino-5-bromopyridine-2-carboxylate in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/81178 A2, 2006 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: mercapto acetic acid ethylester With sodium hydride in N,N-dimethyl-formamide
T=0°C; 1 h;
2: methyl 6-amino-5-bromopyridine-2-carboxylate in N,N-dimethyl-formamide
T=20°C;
参考文献
Brooks, Gerald; Dabbs, Steven; Davies, David T.; Hennessy, Alan J.; Jones, Graham E.; Markwell, Roger E.; Miles, Timothy J.; Owston, Nathan A.; Pearson, Neil D.; Peng, Tony W.
Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5035 - 5037
反应条件
1: 2-mercaptoacetic acid methyl ester With sodium hydride in N,N-dimethyl-formamide
1 h;
2: methyl 6-amino-5-bromopyridine-2-carboxylate in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
Patent: US2010/324030 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.42 h / 0 °C
1.2: 4 h
2.1: water; sodium hydroxide / 1,4-dioxane / 16 h / 23 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BURKE, Michael J.; MCKIBBEN, Bryan; TSCHANTZ, Matt Aaron
Patent: WO2013/191984 A1, 2013 ;
