7-溴-4-羟基-2-萘羧酸乙酯合成路线 （共 5 条）
反应条件
1: With potassium tert-butylate in tert-butyl alcohol T=55 - 85°C; 2 h; 2: With sodium acetate; acetic anhydride T=140°C; 6 h; 3: With potassium carbonate in ethanol T=80°C; 1 h;
参考文献
WO2013/148631 A1, ;
Page/Page column 39; 40 ;
反应条件
potassium carbonate in ethanol 1 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 61, # 15 p. 4894 - 4912
反应条件
hydrogenchloride; potassium tert-butylate; sodium acetate in aqueous Na2 CO3; tert-butyl alcohol
反应条件
1: 100 percent / K2CO3, Bu4NI / dimethylformamide / 11 h / 25 °C 2: 96 percent / dimethylformamide / 20 h / Heating 3: 100 percent / LiOH / tetrahydrofuran; methanol; H2O / 25 h / 25 °C View Scheme
参考文献
Boger, Dale L.; Han, Nianhe; Tarby, Christine M.; Boyce, Christopher W.; Cai, Hui; Jin, Qing; Kitos, Paul A.
Journal of Organic Chemistry, 1996 , vol. 61, # 15 p. 4894 - 4912
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate in N,N-dimethyl-formamide T=85°C; Suzuki Coupling; 2.5 h; Inert atmosphere;
参考文献
Barrett, Matthew O.; Sesma, Juliana I.; Ball, Christopher B.; Jayasekara, P. Suresh; Jacobson, Kenneth A.; Lazarowski, Eduardo R.; Harden, T. Kendall
Molecular Pharmacology, 2013 , vol. 84, # 1 p. 41 - 49
