(4S)-4-羟基-D-脯氨酸甲酯合成路线

参考文献

Rawson, David J.; Brugier, Delphine; Harrison, Anthony; Hough, Jo; Newman, Julie; Otterburn, Joe; Maw, Graham N.; Price, Jenny; Thompson, Lisa R.; Turnpenny, Paul; Warren, Andrew N.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3771 - 3773

67-56-1甲醇

178962-09-9(4S)-4-羟基-D-脯氨酸甲酯

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/108358 A2, 2005 ;
Location in patent: Page/Page column 38 ;
WO 2005/108358 A2

178962-09-9(4S)-4-羟基-D-脯氨酸甲酯

256487-77-1N-Boc-4-羰基-L-脯氨酸甲酯

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3771 - 3773

178962-09-9(4S)-4-羟基-D-脯氨酸甲酯

1123307-53-8

参考文献

Laine, Dramane; Palovich, Michael; McCleland, Brent; Petitjean, Emilie; Delhom, Isabelle; Xie, Haibo; Deng, Jianghe; Lin, Guoliang; Davis, Roderick; Jolit, Anais; Nevins, Neysa; Zhao, Baoguang; Villa, Jim; Schneck, Jessica; McDevitt, Patrick; Midgett, Robert; Kmett, Casey; Umbrecht, Sandra; Peck, Brian; Davis, Alicia Bacon; Bettoun, David
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 2 p. 142 - 147

178962-09-9(4S)-4-羟基-D-脯氨酸甲酯

77450-03-4(2R,4S)-4-羟基-2-(羟甲基)-1-吡咯烷羧酸叔丁酯

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60