trimethylamine-N-oxide; triethylamine; hexacarbonyl molybdenum in diethyl ether T=20°C; 12 h;

1: pyridine / CH2Cl2 / 13 h / 20 °C 2: 1.) SnCl2, 2.) aq. KF / 1.) MeOH, 20 deg C, 19 h, 2.) EtOAc, 1.5 h 3: methanol; H2O / 1 h / 20 °C 4: 89 percent / Mo(CO)6, Et3N / diethyl ether / 60 h / 20 °C 5: AcOH / CH2Cl2 6: pyridine, (4-dimethylamino)pyridine / CH2Cl2 7: 73 percent / trimethylsilyl trifluorosulfonate, 3 Angstroem sieves / 1,2-dichloro-ethane / 83 °C 8: 61 percent / NaOMe / methanol / 65 °C View Scheme