(3R,4R,5R,6R)-氮杂环庚烷-3,4,5,6-四醇盐酸盐合成路线 （共 13 条）
反应条件
1: pyridine / 24 h / 50 °C
2: pyridine / 24 h / 20 °C
3: 98 percent / aq. CF3COOH / 0.08 h
4: 89 percent / pyridine / 24 h / 20 °C
5: 93 percent / MeONa / dimethylformamide / 0.25 h / 40 °C / 20 Torr
6: 97 percent / NaOMe / methanol / 4 h / 20 °C
7: Cl2 / CH2Cl2 / 0.25 h / 0 °C
8: 58 percent / NaCNBH3 / acetic acid / 24 h / 20 °C
View Scheme
参考文献
Fuentes, Jose; Gasch, Consolacion; Olano, David; Pradera; Repetto, Guillermo; Sayago, Francisco J.
Tetrahedron Asymmetry, 2002 , vol. 13, # 16 p. 1743 - 1753
反应条件
1: Cl2 / CH2Cl2 / 0.25 h / 0 °C
2: 58 percent / NaCNBH3 / acetic acid / 24 h / 20 °C
View Scheme
参考文献
Fuentes, Jose; Gasch, Consolacion; Olano, David; Pradera; Repetto, Guillermo; Sayago, Francisco J.
Tetrahedron Asymmetry, 2002 , vol. 13, # 16 p. 1743 - 1753
反应条件
1: 1.) caesium acetate, 2.) K2CO3, MeOH / 1.) DMF, 40-50 deg C, 24 h, 2.) 20 deg C, 1 h
2: 100 percent / H2, AcOH / Pd black / 18 h
View Scheme
参考文献
Le Merrer, Yves; Poitout, Lydie; Depezay, Jean-Claude; Dosbaa, Isabelle; Geoffroy, Sabine; Foglietti, Marie-Jose
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 519 - 533
