4-甲氧基-2-甲基-1H-吲哚合成路线 （共 7 条）
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 32 h;
参考文献
ILYPSA, INC.
Patent: WO2007/56280 A1, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/056280 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=20°C; 288.48 h; Heating / reflux; 2: With water; ammonium chloride in tetrahydrofuran; hexanes T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/49113 A1, 2009 ;
Location in patent: Page/Page column 20 ;
WO 2009/049113 A1
反应条件
sodium amide; sodium t-butanolate in tetrahydrofuran; tert-butyl alcohol 0 deg C -> room temp., 24 h;
参考文献
Caubere, Catherine; Caubere, Paul; Ianelli, Sandra; Nardelli, Mario; Jamart-Gregoire, Brigitte
Tetrahedron, 1994 , vol. 50, # 41 p. 11903 - 11920
反应条件
1: 1.) s-BuLi / 1.) cyclohexanone, THF, -40 deg C, 0.25 h, 2.) cyclohexanone, THF, from -40 deg C to RT, 2 h 2: CF3COOH / CH2Cl2 / 26 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5119 - 5136
反应条件
1: 73 percent / tetrahydrofuran / 2 h / Heating 2: 1.) s-BuLi / 1.) cyclohexanone, THF, -40 deg C, 0.25 h, 2.) cyclohexanone, THF, from -40 deg C to RT, 2 h 3: CF3COOH / CH2Cl2 / 26 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5119 - 5136
反应条件
1: benzene / Heating 2: 66 percent / NaNH2-t-BuONa / 2-methyl-propan-2-ol; tetrahydrofuran / 0 deg C -> room temp., 24 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11903 - 11920
