1: 2,6-difluoromethoxybenzene With lithium diisopropyl amide in tetrahydrofuran; hexanes T=-78°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran; hexanes T=-78 - -20°C; 0.5 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexanes pH=~ 2;

1: 2,6-Difluoro-phenol; methyl iodide With potassium carbonate in N,N-dimethyl-formamide T=50°C; 2: carbon dioxide With n-butyllithium in tetrahydrofuran T=-78°C;

暂无反应条件数据

1: K2CO3; KOH / dimethylsulfoxide / 20 °C 2: BBr3 / CH2Cl2 / -30 - 0 °C View Scheme

in tetrahydrofuran; N-methyl-acetamide; dichloromethane