4-[3-(甲氧羰基)苯基]-1-哌嗪羧酸叔丁酯合成路线 （共 4 条）
反应条件
sodium t-butanolate; palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane in toluene T=50°C;
参考文献
SCHERING CORPORATION
Patent: WO2007/97937 A1, 2007 ;
Location in patent: Page/Page column 181-182 ;
WO 2007/097937 A1
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
反应条件
1: potassium carbonate / butan-1-ol / 177 h / |Reflux 2: 20 °C View Scheme
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
反应条件
sodium hydroxide; water in ethanol T=60°C;
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
