(5-苯基-1H-吡唑-3-基)甲醇合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3.5 h; Ambient temperature;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 59 percent / NaH / dimethylformamide / 1.5 h / 20 - 50 °C 2: 51 percent / H2NNH2*H2O / ethanol / 5 h / Heating 3: 38 percent / LiAlH4 / tetrahydrofuran / 3.5 h / Ambient temperature View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 51 percent / H2NNH2*H2O / ethanol / 5 h / Heating 2: 38 percent / LiAlH4 / tetrahydrofuran / 3.5 h / Ambient temperature View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h 1.2: ZnCl2 / tetrahydrofuran; hexane / 1 h / 0 °C 1.3: 49 percent / tetrahydrofuran; hexane / 0.5 h / 40 °C 2.1: 98 percent / hydrazine monohydrate / methanol / 1 h 3.1: 3.41 g / aqueous HCl / methanol / 15 h / pH 2 / Heating View Scheme
参考文献
Grotjahn, Douglas B.; Van, Sang; Combs, David; Lev, Daniel A.; Schneider, Christian; Rideout, Marc; Meyer, Christoph; Hernandez, Genaro; Mejorado, Lupe
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9200 - 9209
反应条件
lithium aluminium tetrahydride
参考文献
Jones et al.
Journal of Organic Chemistry, 1954 , vol. 19, p. 1428,1431
