(7-氯苯并[d][1,3]二氧代l-5-基)甲醇合成路线 （共 4 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: caesium carbonate / N,N-dimethyl-formamide 2: sodium tetrahydroborate / tetrahydrofuran View Scheme
参考文献
BASF SE; BASF SCHWEIZ AG; KÖRBER, Karsten; KAISER, Florian; VEITCH, Gemma; VON DEYN, Wolfgang; BANDUR, Nina Gertrud; DICKHAUT, Joachim; NARINE, Arun; CULBERTSON, Deborah L.; NEESE, Paul; GUNJIMA, Koshi
Patent: WO2013/164295 A1, 2013 ;
反应条件
1: dichloromethane 2: caesium carbonate / N,N-dimethyl-formamide 3: sodium tetrahydroborate / tetrahydrofuran View Scheme
参考文献
BASF SE; BASF SCHWEIZ AG; KÖRBER, Karsten; KAISER, Florian; VEITCH, Gemma; VON DEYN, Wolfgang; BANDUR, Nina Gertrud; DICKHAUT, Joachim; NARINE, Arun; CULBERTSON, Deborah L.; NEESE, Paul; GUNJIMA, Koshi
Patent: WO2013/164295 A1, 2013 ;
反应条件
1: chlorine / acetic acid / 1 h / 25 °C 2: boron tribromide / dichloromethane / -40 °C / |Inert atmosphere 3: caesium carbonate / N,N-dimethyl-formamide / 60 °C 4: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
BASF SE; BASF SCHWEIZ AG; KÖRBER, Karsten; KAISER, Florian; VEITCH, Gemma; VON DEYN, Wolfgang; BANDUR, Nina Gertrud; DICKHAUT, Joachim; NARINE, Arun; CULBERTSON, Deborah L.; NEESE, Paul; GUNJIMA, Koshi
Patent: WO2013/164295 A1, 2013 ;
