1: With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran; toluene T=20°C; 15 h; Inert atmosphere; 2: With boric acid trimethyl ester in tetrahydrofuran; toluene T=0°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; toluene T=0°C; Inert atmosphere;

phenyl sulphuryl chloride; C43H43NO3PPdS; sodium carbonate in acetone T=65°C; 12 h; Inert atmosphereSealed tube;

palladium diacetate; tetrabutylammomium bromide; potassium carbonate in water T=25°C; 16 h;

sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene RefluxInert atmosphere;

1.1: copper diacetate / dichloromethane / 0.08 h / 20 °C / |Molecular sieve 1.2: 45 °C 2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme