2-(2-丙炔-1-基)丙二酸二乙酯合成路线 （共 24 条）
反应条件
1: 41.1 percent / EtONa / ethanol / 6 h / Heating 2: 99 percent / aq. NaOH / ethanol / 3 h / Heating 3: 83.8 percent / 3 h / 130 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 12 p. 3282 - 3294
反应条件
1: (2-propynyl)propanedioic acid diethyl ester With sodium hydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: allyl bromide in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
Benedetti, Erica; Simonneau, Antoine; Hours, Alexandra; Amouri, Hani; Penoni, Andrea; Palmisano, Giovanni; Malacria, Max; Goddard, Jean-Philippe; Fensterbank, Louis
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1908 - 1912
反应条件
1: (2-propynyl)propanedioic acid diethyl ester With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: propargyl bromide T=0 - 20°C; 20.5 h; Inert atmosphere;
参考文献
Trost, Barry M.; Breder, Alexander; Okeefe, B. Michael; Rao, Meera; Franz, Adam W.
Journal of the American Chemical Society, 2011 , vol. 133, # 13 p. 4766 - 4769
反应条件
1: 67 g / NaCl / dimethylsulfoxide; H2O / 40 h / Heating 2: 35.5 g / aq. KOH / methanol / 4 h / Heating View Scheme
参考文献
Derzhinskii,A.R. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1965 , p. 1197 - 1201
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1965 , p. 1237 - 1241
反应条件
1: 69.6 percent / EtONa / ethanol / 6 h / Heating 2: 98.2 percent / aq. NaOH / ethanol / 3 h / Heating 3: 58.2 percent / 3 h / 140 °C View Scheme
参考文献
Wu, Zhixing; Minhas, Gurpreet Singh; Wen, Dingyi; Jiang, Hualiang; Chen, Kaixian; Zimniak, Piotr; Zheng, Jiang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3282 - 3294
反应条件
1: 67 g / NaCl / dimethylsulfoxide; H2O / 40 h / Heating 2: 35.5 g / aq. KOH / methanol / 4 h / Heating 3: 1.) EtMgBr, 2.) CuCN, HMPT / 1.) THF, RT, 2 h, 2.) THF, 3 h 4: 79 percent / conc. H2SO4 / CCl4 / 10 h View Scheme
参考文献
Revue Roumaine de Chimie, , vol. 40, # 3 p. 253 - 258
参考文献
Perkin jun.; Simonsen
Journal of the Chemical Society, 1907 , vol. 91, p. 823
反应条件
sodium ethanolate in tetrahydrofuran
T=20°C; 2 h;
参考文献
Brummond, Kay M.; Chen, Hongfeng; Sill, Peter; You, Lingfeng
Journal of the American Chemical Society, 2002 , vol. 124, # 51 p. 15186 - 15187
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 506005/; Multistep reaction;
参考文献
Derzhinskii,A.R. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1965 , p. 1197 - 1201
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1965 , p. 1237 - 1241
反应条件
zinc in N,N-dimethyl-formamide
T=60°C; 10 h; Inert atmosphere;
参考文献
Yadav; Reddy, B. V. Subba; Mishra, Anand Kumar
Chemistry Letters, 2010 , vol. 39, # 3 p. 280 - 281
