2-(2-丙炔-1-基)丙二酸二乙酯合成路线 （共 24 条）
反应条件
1: diethyl malonate With sodium ethanolate in ethanol
1 h;
2: propargyl bromide in ethanol; toluene
T=0 - 20°C; 21 h;
参考文献
Czekelius, Constantin; Hafer, Jillian; Tonzetich, Zachary J.; Schrock, Richard R.; Christensen, Ronald L.; Mueller, Peter
Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16664 - 16675
反应条件
1: in N,N-dimethyl-formamide; toluene
T=80°C; 1.5 h;
2: With sodium ethanolate in tetrahydrofuran
T=20°C; 1 h;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2172450 A1, 2010 ;
Location in patent: Page/Page column 68-69 ;
EP 2172450 A1
反应条件
potassium carbonate in acetonitrile
24 h; Heating / reflux;
参考文献
INDIAN INSTITUTE OF TECHNOLOGY BOMBAY
Patent: WO2006/117800 A2, 2006 ;
Location in patent: Page/Page column 16 ;
参考文献
Schulte; Reiss
Chemische Berichte, 1954 , vol. 87, p. 964,969
Full Text Show Details
Eglinton; Whiting
Journal of the Chemical Society, 1953 , p. 3052,3055
参考文献
Perkin jun.; Simonsen
Journal of the Chemical Society, 1907 , vol. 91, p. 823
参考文献
Colonge; Gelin
Bulletin de la Societe Chimique de France, 1954 , p. 797
反应条件
1.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 22 °C
1.2: 79 percent / tetrahydrofuran; various solvent(s) / 2 h / 22 °C
2.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 20 °C
2.2: 85 percent / tetrahydrofuran; various solvent(s) / 3 h / 20 °C
View Scheme
参考文献
Bennacer, Bibia; Fujiwara, Masaki; Lee, Seung-Yub; Ojima, Iwao
Journal of the American Chemical Society, 2005 , vol. 127, # 50 p. 17756 - 17767
反应条件
diisopropylamine; copper(I) bromide in 1,4-dioxane
Heating;
参考文献
Oh, Chang Ho; Gupta, Arun Kumar; Park, Dai In; Kim, Nakjoong
Chemical Communications, 2005 , # 45 p. 5670 - 5672
反应条件
1.1: NaH / dimethylformamide; various solvent(s)
1.2: NaI / dimethylformamide; various solvent(s) / 40 h
1.3: 53 percent / aq. HCl / dimethylformamide / 4 h
2.1: RuCp(NCMe)3PF6 / acetone; H2O / 1.5 h / 60 °C
3.1: n-BuLi / tetrahydrofuran / -78 - 20 °C
3.2: 14 percent / tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Czekelius, Constantin; Hafer, Jillian; Tonzetich, Zachary J.; Schrock, Richard R.; Christensen, Ronald L.; Mueller, Peter
Journal of the American Chemical Society, 2006 , vol. 128, # 51 p. 16664 - 16675
反应条件
1: aq. lithium chloride / dimethylsulfoxide / Heating
2: 10percent aq. sodium hydroxide / ethanol
3: oxalyl chloride
View Scheme
参考文献
Tokuda, Masao; Fujita, Hirotake; Nitta, Makoto; Suginome, Hiroshi
Heterocycles, 1996 , vol. 42, # 1 p. 385 - 395
